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Basically just know this “brain defect” theory is horseshit and has never been proven to be true. Studies have shown the significant effect of sleep deprivation on disrupting or heightening emotions, as well as the relation between lack of sleep and conditions such as anxiety and depression. The classic “rhodiola picture” would be someone with a high level of stress/fatigue who also suffers from low mood. Mindfulness is not thinking about the past, or future, or even the present… mindfulness is about experiencing the moment.