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When Goliath shouted out to the Israelites, he was asking for what was known as “single combat.” This was a common practice in the ancient world. Let’s dig a little deeper into this strange association between what is essentially a neurological malfunction and career success. Notes Introduction: Goliath The scholarly literature on the battle between David and Goliath is extensive. Li hit choriocarcinoma—a rare cancer of the uterus—with round after round of methotrexate until he finally drove it from his patients’ bodies.