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This guide is organized to mirror the clinical approach. Sometimes, their behavior during these high periods seems strange or annoying to others____. The newer dopamine agonists appear to be free of that risk, which is caused by activation of 5-HT2B serotonergic receptors on the heart. The treatment is typically lowered gradually over several months, first from five days a week to three days a week, then two days a week, and finally to monthly treatments.